GDF5 PROGENITORS GIVE RISE TO FIBROCARTILAGE CELLS THAT MINERALIZE VIA HEDGEHOG SIGNALING TO FORM THE ZONAL ENTHESIS

The sequence of events that leads to the formation of a functionally graded enthesis is not clearly defined. The current study demonstrates that clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis. Prior to mineralization, Col1+ cells in the enthesis appose Col2+ cells...

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Bibliografiske detaljer
Udgivet i:Dev Biol
Main Authors: Dyment, Nathaniel A., Breidenbach, Andrew P., Schwartz, Andrea G., Russell, Ryan P., Aschbacher-Smith, Lindsey, Liu, Han, Hagiwara, Yusuke, Jiang, Rulang, Thomopoulos, Stavros, Butler, David L., Rowe, David W.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529782/
https://ncbi.nlm.nih.gov/pubmed/26141957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.06.020
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