NF-kappaB2/p52:c-Myc:hnRNPA1 pathway regulates expression of androgen receptor splice variants and enzalutamide sensitivity in prostate cancer

Castration resistant prostate cancer (CRPC) remains dependent on androgen receptor (AR) signaling. Alternative splicing of the AR to generate constitutively active, ligand-independent variants is one of the principal mechanisms that promote the development of resistance to next-generation anti-andro...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Nadiminty, Nagalakshmi, Tummala, Ramakumar, Liu, Chengfei, Lou, Wei, Evans, Christopher P., Gao, Allen C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529751/
https://ncbi.nlm.nih.gov/pubmed/26056150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-1057
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