NF-kappaB2/p52:c-Myc:hnRNPA1 pathway regulates expression of androgen receptor splice variants and enzalutamide sensitivity in prostate cancer

Castration resistant prostate cancer (CRPC) remains dependent on androgen receptor (AR) signaling. Alternative splicing of the AR to generate constitutively active, ligand-independent variants is one of the principal mechanisms that promote the development of resistance to next-generation anti-andro...

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Publicado en:Mol Cancer Ther
Autores principales: Nadiminty, Nagalakshmi, Tummala, Ramakumar, Liu, Chengfei, Lou, Wei, Evans, Christopher P., Gao, Allen C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529751/
https://ncbi.nlm.nih.gov/pubmed/26056150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-1057
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