Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response

OBJECTIVE: Central administration of ligands for fibroblast growth factor receptors (FGFRs) such as fibroblast growth factor-19 (FGF19) and FGF21 exert glucose-lowering effects in rodent models of obesity and type 2 diabetes (T2D). Conversely, intracerebroventricular (icv) administration of the non-...

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Publicado en:Mol Metab
Autores principales: Rojas, Jennifer M., Matsen, Miles E., Mundinger, Thomas O., Morton, Gregory J., Stefanovski, Darko, Bergman, Richard N., Kaiyala, Karl J., Taborsky, Gerald J., Schwartz, Michael W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
Materias:
Brief Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529498/
https://ncbi.nlm.nih.gov/pubmed/26266088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.05.005
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