Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

Nicotinamide N-methyltransferase (Nnmt) methylates nicotinamide, a form of vitamin B3, to produce N1-methylnicotinamide (MNAM). Nnmt is an emerging metabolic regulator in adipocytes but its role in the liver, a tissue with the strongest Nnmt expression, is not known. In spite of its overall high exp...

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Vydáno v:Nat Med
Hlavní autoři: Hong, Shangyu, Moreno-Navarrete, Jose M, Wei, Xiaojing, Kikukawa, Yusuke, Tzameli, Iphigenia, Prasad, Deepthi, Lee, Yoonjin, Asara, John M, Fernandez-Real, Jose Manuel, Maratos-Flier, Eleftheria, Pissios, Pavlos
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529375/
https://ncbi.nlm.nih.gov/pubmed/26168293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3882
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