A Phase I Double Blind, Placebo-Controlled, Randomized Study of the Safety and Immunogenicity of Electroporated HIV DNA with or without Interleukin 12 in Prime-Boost Combinations with an Ad35 HIV Vaccine in Healthy HIV-Seronegative African Adults

BACKGROUND: Strategies to enhance the immunogenicity of DNA vaccines in humans include i) co-administration of molecular adjuvants, ii) intramuscular administration followed by in vivo electroporation (IM/EP) and/or iii) boosting with a different vaccine. Combining these strategies provided protecti...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mpendo, Juliet, Mutua, Gaudensia, Nyombayire, Julien, Ingabire, Rosine, Nanvubya, Annet, Anzala, Omu, Karita, Etienne, Hayes, Peter, Kopycinski, Jakub, Dally, Len, Hannaman, Drew, Egan, Michael A., Eldridge, John H., Syvertsen, Kristen, Lehrman, Jennifer, Rasmussen, Beth, Gilmour, Jill, Cox, Josephine H., Fast, Patricia E., Schmidt, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529153/
https://ncbi.nlm.nih.gov/pubmed/26252526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134287
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