A(3) adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways

Chemotherapy-induced peripheral neuropathy (CIPN) accompanied by chronic neuropathic pain is the major dose-limiting toxicity of several anticancer agents including the taxane paclitaxel (Taxol(®)). A critical mechanism underlying paclitaxel-induced neuropathic pain is the increased production of pe...

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Publicado en:Pain
Autores principales: Janes, Kali, Esposito, Emanuela, Doyle, Timothy, Cuzzocrea, Salvatore, Tosh, Dillip K., Jacobson, Kenneth A., Salvemini, Daniela
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529068/
https://ncbi.nlm.nih.gov/pubmed/25242567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2014.09.016
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