Transcriptome Analysis of Pig In Vivo, In Vitro–Fertilized, and Nuclear Transfer Blastocyst-Stage Embryos Treated with Histone Deacetylase Inhibitors Postfusion and Activation Reveals Changes in the Lysosomal Pathway

Genetically modified pigs are commonly created via somatic cell nuclear transfer (SCNT). Treatment of reconstructed embryos with histone deacetylase inhibitors (HDACi) immediately after activation improves cloning efficiency. The objective of this experiment was to evaluate the transcriptome of SCNT...

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Publicat a:Cell Reprogram
Autors principals: Whitworth, Kristin M., Mao, Jiude, Lee, Kiho, Spollen, William G., Samuel, Melissa S., Walters, Eric M., Spate, Lee D., Prather, Randall S.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529055/
https://ncbi.nlm.nih.gov/pubmed/26731590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2015.0022
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