Gene dosage of CuZnSOD and Down's syndrome: diminished prostaglandin synthesis in human trisomy 21, transfected cells and transgenic mice.

Patients with Down's syndrome (DS) exhibit elevated activity of copper zinc superoxide dismutase (CuZnSOD) caused by the trisomy 21 state. To investigate the possible involvement of CuZnSOD gene dosage in perturbation of prostaglandin biosynthesis we analyzed transfected cells and transgenic mice th...

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Vydáno v:	EMBO J
Hlavní autoři:	Minc-Golomb, D, Knobler, H, Groner, Y
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 1991
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452898/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1829676/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb07745.x
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