Gene dosage of CuZnSOD and Down's syndrome: diminished prostaglandin synthesis in human trisomy 21, transfected cells and transgenic mice.

Patients with Down's syndrome (DS) exhibit elevated activity of copper zinc superoxide dismutase (CuZnSOD) caused by the trisomy 21 state. To investigate the possible involvement of CuZnSOD gene dosage in perturbation of prostaglandin biosynthesis we analyzed transfected cells and transgenic mice th...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Minc-Golomb, D, Knobler, H, Groner, Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452898/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1829676/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb07745.x
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