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Microfluidic Gradients Reveal Enhanced Neurite Outgrowth but Impaired Guidance within 3D Matrices with High Integrin Ligand Densities

The density of integrin-binding ligands in an extracellular matrix (ECM) is known to regulate cell migration speed by imposing a balance of traction forces between the leading and trailing edges of the cell, but the effect of cell-adhesive ligands on neurite chemoattraction is not well understood. W...

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Bibliografiske detaljer
Udgivet i:Small
Main Authors: Romano, Nicole H., Lampe, Kyle J., Xu, Hui, Ferreira, Meghaan M., Heilshorn, Sarah C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528974/
https://ncbi.nlm.nih.gov/pubmed/25315156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/smll.201401574
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