A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

Autophagy is an essential eukaryotic pathway requiring tight regulation to maintain homeostasis and preclude disease. Using yeast and mammalian cells, we report a conserved mechanism of autophagy regulation by RNA helicase RCK family members in association with the decapping enzyme Dcp2. Under nutri...

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Pubblicato in:Nat Cell Biol
Autori principali: Hu, Guowu, McQuiston, Travis, Bernard, Amélie, Park, Yoon-Dong, Qiu, Jin, Vural, Ali, Zhang, Nannan, Waterman, Scott R., Blewett, Nathan H., Myers, Timothy G., Maraia, Richard J., Kehrl, John H., Uzel, Gulbu, Klionsky, Daniel J., Williamson, Peter R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528364/
https://ncbi.nlm.nih.gov/pubmed/26098573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3189
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