Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry Enables Multiplex, Quantitative Pharmacodynamic Studies of Phospho-Signaling

In most cell signaling experiments, analytes are measured one Western blot lane at a time in a semiquantitative and often poorly specific manner, limiting our understanding of network biology and hindering the translation of novel therapeutics and diagnostics. We show the feasibility of using multip...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Proteomics
Prif Awduron: Whiteaker, Jeffrey R., Zhao, Lei, Yan, Ping, Ivey, Richard G., Voytovich, Uliana J., Moore, Heather D., Lin, Chenwei, Paulovich, Amanda G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Technological Innovation and Resources
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528251/
https://ncbi.nlm.nih.gov/pubmed/25987412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.O115.050351
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