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Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons
ß-amyloid (Aß(1−42)) is produced by proteolytic cleavage of the transmembrane type-1 protein, amyloid precursor protein. Under pathological conditions, Aß(1−42)self-aggregates into oligomers, which cause synaptic dysfunction and neuronal loss, and are considered the culprit of Alzheimer's disea...
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| Publicado no: | Front Cell Neurosci |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4528168/ https://ncbi.nlm.nih.gov/pubmed/26300732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00297 |
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