The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100

Partial degradation of the p100 subunit to generate p52 subunit is a hallmark of the alternative NF-κB pathway, which has been implicated in cancer. Here, we uncovered a role of the p97-Npl4-Ufd1 complex in mediating p100-to-p52 processing and therefore positively regulating the alternative NF-κB pa...

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Publicado en:J Biol Chem
Autores principales: Zhang, Zhao, Wang, Yanyan, Li, Chuanchuan, Shi, Zhubing, Hao, Qian, Wang, Wenjia, Song, Xiaomin, Zhao, Yun, Jiao, Shi, Zhou, Zhaocai
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528123/
https://ncbi.nlm.nih.gov/pubmed/26112410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630061
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