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Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease

Tricuspid regurgitant (TR) jet velocity and its relationship to pulmonary hypertension has been controversial in sickle cell disease (SCD). Plasma free hemoglobin is elevated in SCD patients and acutely impairs systemic vascular reactivity. We postulated that plasma free hemoglobin would be negative...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Detterich, Jon A., Kato, Roberta M., Rabai, Miklos, Meiselman, Herbert J., Coates, Thomas D., Wood, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528063/
https://ncbi.nlm.nih.gov/pubmed/26036801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-614370
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