Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

Sphingolipids have garnered attention for their role in insulin resistance and lipotoxic cell death. Aberrant accumulation of ceramides correlates with hepatic insulin resistance and steatosis. To further investigate the tissue-specific effects of local changes in ceramidase activity, we have develo...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Xia, Jonathan Y., Holland, William L., Kusminski, Christine M., Sun, Kai, Sharma, Ankit X., Pearson, Mackenzie J., Sifuentes, Angelika J., McDonald, Jeffrey G., Gordillo, Ruth, Scherer, Philipp E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527941/
https://ncbi.nlm.nih.gov/pubmed/26190650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.06.007
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