Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation

The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, by conducting different omics data analyses, we demonstrated that cisplatin induces cell death in a proximal tubular cell line by suppressing glycolysis- and tricarboxylic acid (TCA)/mitochondria-related gene...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Choi, Yong-Min, Kim, Han-Kyul, Shim, Wooyoung, Anwar, Muhammad Ayaz, Kwon, Ji-Woong, Kwon, Hyuk-Kwon, Kim, Hyung Joong, Jeong, Hyobin, Kim, Hwan Myung, Hwang, Daehee, Kim, Hyung Sik, Choi, Sangdun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527592/
https://ncbi.nlm.nih.gov/pubmed/26247588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135083
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