Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder affecting carriers of the fragile X-premutation, who have an expanded CGG repeat in the 5′-UTR of the FMR1 gene. FXTAS is characterized by progressive development of intention tremor, ataxia, parkinsonism...

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Publicat a:Hum Mol Genet
Autors principals: Hukema, Renate K., Buijsen, Ronald A.M., Schonewille, Martijn, Raske, Chris, Severijnen, Lies-Anne W.F.M., Nieuwenhuizen-Bakker, Ingeborg, Verhagen, Rob F.M., van Dessel, Lisanne, Maas, Alex, Charlet-Berguerand, Nicolas, De Zeeuw, Chris I., Hagerman, Paul J., Berman, Robert F., Willemsen, Rob
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527492/
https://ncbi.nlm.nih.gov/pubmed/26060190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv216
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