Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model

Spinocerebellar ataxia type 6 (SCA6) is dominantly inherited neurodegenerative disease, caused by an expansion of CAG repeat encoding a polyglutamine (PolyQ) tract in the Ca(v)2.1 voltage-gated calcium channel. Its key pathological features include selective degeneration of the cerebellar Purkinje c...

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Publié dans:Hum Mol Genet
Auteurs principaux: Aikawa, Tomonori, Mogushi, Kaoru, Iijima-Tsutsui, Kumiko, Ishikawa, Kinya, Sakurai, Miyano, Tanaka, Hiroshi, Mizusawa, Hidehiro, Watase, Kei
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527484/
https://ncbi.nlm.nih.gov/pubmed/26034136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv202
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