A state of reversible compensated ventricular dysfunction precedes pathological remodelling in response to cardiomyocyte-specific activity of angiotensin II type-1 receptor in mice

Cardiac dysfunction is commonly associated with high-blood-pressure-induced cardiomyocyte hypertrophy, in response to aberrant renin-angiotensin system (RAS) activity. Ensuing pathological remodelling promotes cardiomyocyte death and cardiac fibroblast activation, leading to cardiac fibrosis. The in...

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Detalles Bibliográficos
Publicado en:Dis Model Mech
Autores principales: Frentzou, Georgia A., Drinkhill, Mark J., Turner, Neil A., Ball, Stephen G., Ainscough, Justin F. X.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527284/
https://ncbi.nlm.nih.gov/pubmed/26092119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.019174
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