Upregulated IL-1β in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages

BACKGROUND: Loss-of-function mutations in the dysferlin gene (DYSF) result in a family of muscle disorders known collectively as the dysferlinopathies. Dysferlin-deficient muscle is characterized by inflammatory foci and macrophage infiltration with subsequent decline in muscle function. Whereas mac...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Skelet Muscle
Huvudupphovsmän: Cohen, Tatiana V., Many, Gina M., Fleming, Bryan D., Gnocchi, Viola F., Ghimbovschi, Svetlana, Mosser, David M., Hoffman, Eric P., Partridge, Terence A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2015
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527226/
https://ncbi.nlm.nih.gov/pubmed/26251696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-015-0048-4
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk