Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate

Tet (ten-eleven translocation) methylcytosine dioxygenases, which belong to the iron and 2-oxoglutarate (2OG)-dependent dioxygenase superfamily, convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. We recently reported that ascorbate (vitamin C) induces Tet-mediated generation of...

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Bibliographic Details
Published in:Biochem Biophys Res Commun
Main Authors: Dickson, Kevin M., Gustafson, Christopher B., Young, Juan I., Züchner, Stephan, Wang, Gaofeng
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527183/
https://ncbi.nlm.nih.gov/pubmed/24021282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.09.010
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