Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives

BACKGROUND: Streptomyces filipinensis is the industrial producer of filipin, a pentaene macrolide, archetype of non-glycosylated polyenes, and widely used for the detection and the quantitation of cholesterol in biological membranes and as a tool for the diagnosis of Niemann–Pick type C disease. Gen...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Payero, Tamara D, Vicente, Cláudia M, Rumbero, Ángel, Barreales, Eva G, Santos-Aberturas, Javier, de Pedro, Antonio, Aparicio, Jesús F
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527110/
https://ncbi.nlm.nih.gov/pubmed/26246267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0307-4
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