A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus

Antibody (Ab) affinity maturation enables an individual to maintain immunity to an increasing number of pathogens within the limits of a total Ig production threshold. A better understanding of this process is critical for designing vaccines that generate optimal Ab responses to pathogens. Our study...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Frank, Gregory M., Angeletti, Davide, Ince, William L., Gibbs, James S., Khurana, Surender, Wheatley, Adam K., Max, Edward E., McDermott, Adrian B., Golding, Hana, Stevens, James, Bennink, Jack R., Yewdell, Jonathan W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526714/
https://ncbi.nlm.nih.gov/pubmed/26242629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01156-15
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