Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.

To identify the minimum set of polyketide synthase (PKS) components required for in vivo biosynthesis of aromatic polyketides, combinations of genes encoding subunits of three different aromatic PKSs--act from Streptomyces coelicolor A3(2) (an actinorhodin producer), fren from Streptomyces roseofulv...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	McDaniel, R, Ebert-Khosla, S, Fu, H, Hopwood, D A, Khosla, C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45267/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972098/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.24.11542
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