Identification and Assessment of Octreotide Acylation in Polyester Microspheres by LC–MS/MS

PURPOSE: Polyesters with hydrophilic domains, i.e., poly(d,l-lactic-co-glycolic-co-hydroxymethyl glycolic acid) (PLGHMGA) and a multiblock copolymer of poly(ε-caprolactone)-PEG-poly(ε-caprolactone) and poly(l-lactide) ((PC-PEG-PC)-(PL)) are expected to cause less acylation of encapsulated peptides t...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Pharm Res
Main Authors: Shirangi, Mehrnoosh, Hennink, Wim E., Somsen, Govert W., van Nostrum, Cornelus F.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2015
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526596/
https://ncbi.nlm.nih.gov/pubmed/25832500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1685-3
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