Controlled Release of Octreotide and Assessment of Peptide Acylation from Poly(D,L-lactide-co-hydroxymethyl glycolide) Compared to PLGA Microspheres

PURPOSE: To investigate the in vitro release of octreotide acetate, a somatostatin agonist, from microspheres based on a hydrophilic polyester, poly(D,L-lactide-co-hydroxymethyl glycolide) (PLHMGA). METHODS: Spherical and non-porous octreotide-loaded PLHMGA microspheres (12 to 16 μm) and loading eff...

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Main Authors: Ghassemi, Amir H., van Steenbergen, Mies J., Barendregt, Arjan, Talsma, Herre, Kok, Robbert J., van Nostrum, Cornelus F., Crommelin, Daan J. A., Hennink, Wim E.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2011
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246586/
https://ncbi.nlm.nih.gov/pubmed/21744173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0517-3
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