Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain

Histone deacetylases (HDAC’s) became increasingly important targets for therapy of various diseases, resulting in a pressing need to develop HDAC class- and isoform-selective inhibitors. Class IIa deacetylases possess only minimal deacetylase activity against acetylated histones, but have several ot...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bonomi, Robin, Mukhopadhyay, Uday, Shavrin, Aleksandr, Yeh, Hsien-Hsien, Majhi, Anjoy, Dewage, Sajeewa W., Najjar, Amer, Lu, Xin, Cisneros, G. Andrés, Tong, William P., Alauddin, Mian M., Liu, Ren-Shuan, Mangner, Thomas J., Turkman, Nashaat, Gelovani, Juri G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526562/
https://ncbi.nlm.nih.gov/pubmed/26244761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133512
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