An Origin of Cooperative Oxygen Binding of Human Adult Hemoglobin: Different Roles of the α and β Subunits in the α(2)β(2) Tetramer

Human hemoglobin (Hb), which is an α(2)β(2) tetramer and binds four O(2) molecules, changes its O(2)-affinity from low to high as an increase of bound O(2), that is characterized by ‘cooperativity’. This property is indispensable for its function of O(2) transfer from a lung to tissues and is accoun...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nagatomo, Shigenori, Nagai, Yukifumi, Aki, Yayoi, Sakurai, Hiroshi, Imai, Kiyohiro, Mizusawa, Naoki, Ogura, Takashi, Kitagawa, Teizo, Nagai, Masako
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526547/
https://ncbi.nlm.nih.gov/pubmed/26244770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135080
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