[F-18]-Fluoromisonidazole Quantification of Hypoxia in Human Cancer Patients using Image-derived Blood Surrogate Tissue Reference Regions

(18)F-FMISO is the most widely used PET agent for imaging hypoxia, a condition associated with resistance to tumor therapy. (18)F-FMISO equilibrates in normoxic tissues, but is retained under hypoxic conditions because of reduction and binding to macromolecules. A simple tissue-to-blood ratio (TB) i...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Muzi, Mark, Peterson, Lanell M., O’Sullivan, Janet N., Fink, James R., Rajendran, Joseph G., McLaughlin, Lena J., Muzi, John P., Mankoff, David A., Krohn, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526410/
https://ncbi.nlm.nih.gov/pubmed/26112020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.115.158717
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