Implication of a chromosome 15q15.2 locus in regulating UBR1 and predisposing smokers to MGMT methylation in lung

O(6)-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that protects cells from carcinogenic effects of alkylating agents; however, MGMT is silenced by promoter hypermethylation during carcinogenesis. A single nucleotide polymorphism (SNP) in an enhancer in the MGMT promoter was prev...

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Publicado no:Cancer Res
Main Authors: Leng, Shuguang, Wu, Guodong, Collins, Leonard B., Thomas, Cynthia L., Tellez, Carmen S., Jauregui, Andrew R., Picchi, Maria A., Zhang, Xiequn, Juri, Daniel E., Desai, Dhimant, Amin, Shantu G., Crowell, Richard E., Stidley, Christine A., Liu, Yushi, Swenberg, James A., Lin, Yong, Wathelet, Marc G., Gilliland, Frank D., Belinsky, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526392/
https://ncbi.nlm.nih.gov/pubmed/26183928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0243
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