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Heme stabilization of α-Synuclein oligomers during amyloid fibril formation

Alpha-Synuclein (αSyn), which forms amyloid fibrils, is linked to the neuronal pathology of Parkinson’s disease, as it is the major fibrillar component of Lewy bodies, the inclusions that are characteristic of the disease. Oligomeric structures, common to many neurodegenerative disease-related prote...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Hayden, Eric Y., Kaur, Prerna, Williams, Thomas L., Matsui, Hiroshi, Yeh, Syun-Ru, Rousseau, Denis L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526360/
https://ncbi.nlm.nih.gov/pubmed/26161848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00280
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