LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells

Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that act upon the adaptation of cancer cells to hypoxia. LW6, an HIF-1 inhibitor, was hypothesized to improve resistance to cancer therapy in hypoxic tumors by inhibiting the accumulation of HIF-1α. A clear anti-tumor effect und...

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Veröffentlicht in:Mol Med Rep
Hauptverfasser: SATO, MARIKO, HIROSE, KATSUMI, KASHIWAKURA, IKUO, AOKI, MASAHIKO, KAWAGUCHI, HIDEO, HATAYAMA, YOSHIOMI, AKIMOTO, HIROYOSHI, NARITA, YUICHIRO, TAKAI, YOSHIHIRO
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526100/
https://ncbi.nlm.nih.gov/pubmed/26017562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2015.3862
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