Megakaryocytic differentiation in human chronic myelogenous leukemia K562 cells induced by ionizing radiation in combination with phorbol 12-myristate 13-acetate

Differentiation-induction therapy is an attractive approach in leukemia treatment. It has been suggested that the accumulation of intracellular reactive oxygen species (ROS) is involved in megakaryocytic differentiation induced by phorbol 12-myristate 13-acetate (PMA) in the K562 leukemia cell line....

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Main Authors: Hirose, Katsumi, Monzen, Satoru, Sato, Haruka, Sato, Mariko, Aoki, Masahiko, Hatayama, Yoshiomi, Kawaguchi, Hideo, Narita, Yuichiro, Takai, Yoshihiro, Kashiwakura, Ikuo
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650750/
https://ncbi.nlm.nih.gov/pubmed/23263730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rrs125
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