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15-Hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes

15-Hydroxyprostaglandin dehydrogenase (HPGD) is the key enzyme responsible for the metabolic inactivation of prostaglandin E2 (PGE(2)) catabolism. PGE(2) is one of the predominant catabolic factors involved in rheumatoid arthritis (RA). However, the expression and regulation of HPGD in RA fibroblast...

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Bibliografiske detaljer
Udgivet i:Mol Med Rep
Main Authors: KIM, HAK-JAE, LEE, SORA, LEE, HAW-YONG, WON, HANSOL, CHANG, SUNG-HAE, NAH, SEONG-SU
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526038/
https://ncbi.nlm.nih.gov/pubmed/26082314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2015.3931
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