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15-Hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes

15-Hydroxyprostaglandin dehydrogenase (HPGD) is the key enzyme responsible for the metabolic inactivation of prostaglandin E2 (PGE(2)) catabolism. PGE(2) is one of the predominant catabolic factors involved in rheumatoid arthritis (RA). However, the expression and regulation of HPGD in RA fibroblast...

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Publicat a:Mol Med Rep
Autors principals: KIM, HAK-JAE, LEE, SORA, LEE, HAW-YONG, WON, HANSOL, CHANG, SUNG-HAE, NAH, SEONG-SU
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526038/
https://ncbi.nlm.nih.gov/pubmed/26082314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2015.3931
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