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Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis

BACKGROUND: Despite the prevalence of rhinosinusitis that affects 10%–15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and l...

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Bibliografski detalji
Izdano u:Int J Nanomedicine
Glavni autori: Xi, Jinxiang, Yuan, Jiayao Eddie, Si, Xiuhua April, Hasbany, James
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525801/
https://ncbi.nlm.nih.gov/pubmed/26257521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S87382
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