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Properties of Switch-like Bioregulatory Networks Studied by Simulation of the Hypoxia Response Control System

A complex bioregulatory network could be more easily comprehended if its essential function could be described by a small “core” subsystem, and if its response characteristics were switch-like. We tested this proposition by simulation studies of the hypoxia response control network. We hypothesized...

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Detalhes bibliográficos
Main Authors: Kohn, Kurt W., Riss, Joseph, Aprelikova, Olga, Weinstein, John N., Pommier, Yves, Barrett, J. Carl
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC452562/
https://ncbi.nlm.nih.gov/pubmed/15107465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-12-0897
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