Sequence variants at the TERT- CLPTM1L locus associate with many cancer types

The common sequence variants that have recently been associated with cancer risk are particular to a single, or at most two, cancer types. Following up on our genome-wide scan of basal cell carcinoma(1), we identified rs401681(C) on chromosome 5p15.33 satisfying our threshold for genome-wide signifi...

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Publicat a:Nat Genet
Autors principals: Rafnar, Thorunn, Sulem, Patrick, Stacey, Simon N., Geller, Frank, Gudmundsson, Julius, Sigurdsson, Asgeir, Jakobsdottir, Margret, Helgadottir, Hafdis, Thorlacius, Steinunn, Aben, Katja K.H., Blöndal, Thorarinn, Thorgeirsson, Thorgeir E., Thorleifsson, Gudmar, Kristjansson, Kristleifur, Thorisdottir, Kristin, Ragnarsson, Rafn, Sigurgeirsson, Bardur, Skuladottir, Halla, Gudbjartsson, Tomas, Isaksson, Helgi J., Einarsson, Gudmundur V., Benediktsdottir, Kristrun R., Agnarsson, Bjarni A., Olafsson, Karl, Salvarsdottir, Anna, Bjarnason, Hjordis, Asgeirsdottir, Margret, Kristinsson, Kari T., Matthiasdottir, Sigurborg, Sveinsdottir, Steinunn G., Polidoro, Silvia, Höiom, Veronica, Botella-Estrada, Rafael, Hemminki, Kari, Rudnai, Peter, Bishop, D. Timothy, Campagna, Marcello, Kellen, Eliane, Zeegers, Maurice P., de Verdier, Petra, Ferrer, Ana, Isla, Dolores, Vidal, Maria Jesus, Andres, Raquel, Saez, Berta, Juberias, Pablo, Banzo, Javier, Navarrete, Sebastian, Tres, Alejandro, Kan, Donghui, Lindblom, Annika, Gurzau, Eugene, Koppova, Kvetoslava, de Vegt, Femmie, Schalken, Jack A., van der Heijden, Henricus F.M., Smit, Hans J., Termeer, René A., Oosterwijk, Egbert, van Hooij, Onno, Nagore, Eduardo, Porru, Stefano, Steineck, Gunnar, Hansson, Johan, Buntinx, Frank, Catalona, William J., Matullo, Giuseppe, Vineis, Paolo, Kiltie, Anne E., Mayordomo, José I., Kumar, Rajiv, Kiemeney, Lambertus A., Frigge, Michael L., Jonsson, Thorvaldur, Saemundsson, Hafsteinn, Barkardottir, Rosa B., Jonsson, Eirikur, Jonsson, Steinn, Olafsson, Jon H., Gulcher, Jeffrey R., Masson, Gisli, Gudbjartsson, Daniel F., Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525478/
https://ncbi.nlm.nih.gov/pubmed/19151717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.296
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