A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae

Non-typeable Haemophilus influenzae contains an N(6)-adenine DNA-methyltransferase (ModA) that is subject to phase-variable expression (random ON/OFF switching). Five modA alleles, modA2, modA4, modA5, modA9 and modA10, account for over two-thirds of clinical otitis media isolates surveyed. Here, we...

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Publié dans:Nat Commun
Auteurs principaux: Atack, John M., Srikhanta, Yogitha N., Fox, Kate L., Jurcisek, Joseph A., Brockman, Kenneth L., Clark, Tyson A., Boitano, Matthew, Power, Peter M., Jen, Freda E.-C., McEwan, Alastair G., Grimmond, Sean M., Smith, Arnold L., Barenkamp, Stephen J., Korlach, Jonas, Bakaletz, Lauren O., Jennings, Michael P.
Format: Artigo
Langue:Inglês
Publié: Nature Pub. Group 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525171/
https://ncbi.nlm.nih.gov/pubmed/26215614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8828
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