AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings

Adiponectin (APN) is a cardioprotective molecule. Its reduction in diabetes exacerbates myocardial ischemia/reperfusion (MI/R) injury. Although APN administration in animals attenuates MI/R injury, multiple factors limit its clinical application. The current study investigated whether AdipoRon, the...

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Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Zhang, Yanqing, Zhao, Jianli, Li, Rui, Lau, Wayne Bond, Yuan, Yue-Xing, Liang, Bin, Li, Rong, Gao, Er-He, Koch, Walter J., Ma, Xin-Liang, Wang, Ya-Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525114/
https://ncbi.nlm.nih.gov/pubmed/26037251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00577.2014
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