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Mutagenesis of a stacking contact in the MS2 coat protein-RNA complex.

The thermodynamic contribution of a stacking interaction between Tyr85 in MS2 coat protein and a single-stranded pyrimidine in its RNA binding site has been examined. Mutation of Tyr85 to Phe, His, Cys, Ser and Ala decreased the RNA affinity by 1-3 kcal/mol under standard binding conditions. Since t...

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Autori principali: LeCuyer, K A, Behlen, L S, Uhlenbeck, O C
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC452510/
https://ncbi.nlm.nih.gov/pubmed/9003760
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