Expressing Constitutively Active Rheb in Adult Neurons after a Complete Spinal Cord Injury Enhances Axonal Regeneration beyond a Chondroitinase-Treated Glial Scar

After a spinal cord injury (SCI), CNS axons fail to regenerate, resulting in permanent deficits. This is due to: (1) the presence of inhibitory molecules, e.g., chondroitin sulfate proteoglycans (CSPG), in the glial scar at the lesion; and (2) the diminished growth capacity of adult neurons. We soug...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Wu, Di, Klaw, Michelle C., Connors, Theresa, Kholodilov, Nikolai, Burke, Robert E., Tom, Veronica J.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524976/
https://ncbi.nlm.nih.gov/pubmed/26245968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0719-15.2015
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