Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.
We show here that c-Myc antagonizes the cyclin-dependent kinase (CDK) inhibitor p27Kip1. p27 expressed from recombinant retroviruses in Rat1 cells associated with and inhibited cyclin E/CDK2 complexes, induced accumulation of the pRb and p130 proteins in their hypophosphorylated forms, and arrested...
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| Udgivet i: | EMBO J |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
1996
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452484/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8978686/ |
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