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Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.

We show here that c-Myc antagonizes the cyclin-dependent kinase (CDK) inhibitor p27Kip1. p27 expressed from recombinant retroviruses in Rat1 cells associated with and inhibited cyclin E/CDK2 complexes, induced accumulation of the pRb and p130 proteins in their hypophosphorylated forms, and arrested...

詳細記述

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書誌詳細
主要な著者: Vlach, J, Hennecke, S, Alevizopoulos, K, Conti, D, Amati, B
フォーマット: Artigo
言語:Inglês
出版事項: 1996
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC452484/
https://ncbi.nlm.nih.gov/pubmed/8978686
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