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Profile of veliparib and its potential in the treatment of solid tumors

Inhibition of poly(ADP-ribose) polymerase (PARP) is an attractive therapeutic strategy because of the importance of this pathway in restoring DNA damage. Small-molecule inhibitors of PARP appear most effective when used to treat tumors with underlying defects in DNA repair, or when combined with DNA...

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Vydáno v:Onco Targets Ther
Hlavní autor: Wagner, Lars M
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524591/
https://ncbi.nlm.nih.gov/pubmed/26251615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S69935
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