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Profile of veliparib and its potential in the treatment of solid tumors
Inhibition of poly(ADP-ribose) polymerase (PARP) is an attractive therapeutic strategy because of the importance of this pathway in restoring DNA damage. Small-molecule inhibitors of PARP appear most effective when used to treat tumors with underlying defects in DNA repair, or when combined with DNA...
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| Опубликовано в: : | Onco Targets Ther |
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| Главный автор: | |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Dove Medical Press
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4524591/ https://ncbi.nlm.nih.gov/pubmed/26251615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S69935 |
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