A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins

To identify host factors relevant for severe acute respiratory syndrome-coronavirus (SARS-CoV) replication, we performed a small interfering RNA (siRNA) library screen targeting the human kinome. Protein kinases are key regulators of many cellular functions, and the systematic knockdown of their exp...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: de Wilde, Adriaan H., Wannee, Kazimier F., Scholte, Florine E. M., Goeman, Jelle J., ten Dijke, Peter, Snijder, Eric J., Kikkert, Marjolein, van Hemert, Martijn J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524262/
https://ncbi.nlm.nih.gov/pubmed/26041291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01029-15
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