New Insights into the Understanding of Hepatitis C Virus Entry and Cell-to-Cell Transmission by Using the Ionophore Monensin A

In our study, we characterized the effect of monensin, an ionophore that is known to raise the intracellular pH, on the hepatitis C virus (HCV) life cycle. We showed that monensin inhibits HCV entry in a pangenotypic and dose-dependent manner. Monensin induces an alkalization of intracellular organe...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Fénéant, Lucie, Potel, Julie, François, Catherine, Sané, Famara, Douam, Florian, Belouzard, Sandrine, Calland, Noémie, Vausselin, Thibaut, Rouillé, Yves, Descamps, Véronique, Baumert, Thomas F., Duverlie, Gilles, Lavillette, Dimitri, Hober, Didier, Dubuisson, Jean, Wychowski, Czeslaw, Cocquerel, Laurence
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524216/
https://ncbi.nlm.nih.gov/pubmed/26041282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00192-15
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