The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway

When expressed alone at high levels, the human adenovirus E4orf4 protein exhibits tumor cell-specific p53-independent toxicity. A major E4orf4 target is the B55 class of PP2A regulatory subunits, and we have shown recently that binding of E4orf4 inhibits PP2A(B55) phosphatase activity in a dose-depe...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Mui, Melissa Z., Zhou, Yiwang, Blanchette, Paola, Chughtai, Naila, Knight, Jennifer F., Gruosso, Tina, Papadakis, Andreas I., Huang, Sidong, Park, Morag, Gingras, Anne-Claude, Branton, Philip E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2015
Onderwerpen:
Virus-Cell Interactions
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524087/
https://ncbi.nlm.nih.gov/pubmed/26085163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03710-14
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