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The “Funny” Current (I(f)) Inhibition by Ivabradine at Membrane Potentials Encompassing Spontaneous Depolarization in Pacemaker Cells

Recent clinical trials have shown that ivabradine (IVA), a drug that inhibits the funny current (I(f)) in isolated sinoatrial nodal cells (SANC), decreases heart rate and reduces morbidity and mortality in patients with cardiovascular diseases. While IVA inhibits I(f), this effect has been reported...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Yaniv, Yael, Maltsev, Victor A., Ziman, Bruce D., Spurgeon, Harold A., Lakatta, Edward G.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523892/
https://ncbi.nlm.nih.gov/pubmed/22777191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules17078241
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